Advertisement

  • News
  • Columns
  • Interviews
  • BW Communities
  • Events
  • BW TV
  • Subscribe to Print
  • Editorial Calendar 19-20
BW Businessworld

Study highlights genome altering can help to treat human retinal degeneration

Study highlights genome altering can help to treat human retinal degeneration

Photo Credit :

New York [US], January 20 (ANI): A study published in journal Human Gene Therapy shows that gene editing therapies, including CRISPR-Cas frameworks, offer the possibility to address transformations causing inherited retinal degenerations, a leading cause of blindness.
The findings highlight the technological advances in gene editing, continuing safety concerns, and strategies to overcome these challenges.
Kanmin Xue, University of Oxford, and co-authors state, "Currently, the field is undergoing rapid development with a number of competing gene editing strategies, including allele-specific knock-down, base editing, prime editing, and RNA editing, are under investigation. Each offers a different balance of on-target editing efficiency versus off-target risks."
"Testing these newly-developed CRISPR technologies in human retinal tissue, organoids and in vivo will help to highlight the most-viable therapeutic approaches for treating inherited retinal diseases in the future," they added.
Characterizing the rapidly evolving field of CRISPR-Cas based genome editing and current strategies for extending the capabilities of CRISPR-Cas9, the article also features epigenetic editing, the risks of retinal gene editing, and approaches in development to control Cas9 activity and improve safety.
"The eye is an ideal target for in vivo gene editing. Dr Xue's review provides an excellent overview of the current state of the art," says Editor-in-Chief of Human Gene Therapy Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School. (ANI)

Disclaimer: The views expressed in the article above are those of the authors' and do not necessarily represent or reflect the views of this publishing house. Unless otherwise noted, the author is writing in his/her personal capacity. They are not intended and should not be thought to represent official ideas, attitudes, or policies of any agency or institution.


Tags assigned to this article:
genome editing human retinal degenaration health science

ANI

ANI

More From The Author >>